The role of innate muscular endurance and resistance to hypoxia in reactions to acute stress of immunity in rats

Abstract

Background. It is known about aerobic fitness variability between individuals explained by genetics factors. On the other hand, it is also known about a wide variety of individual reactions to stress. From the above it follows the hypothesis that inter-individual differences in normal conditions determine the characteristics of the body's response to acute stress. We have been shown that innate muscular endurance and resistance to hypoxia significantly determines the post-stress neuro-endocrine and metabolic parameters as well as injuries of myocardium and gastric mucosa in rats. The purpose of this study is to test the hypothesis conformably to Immunity. Material and methods. The experiment is at 58 rats (28 males) Wistar line. Animals were first tested for resistance to hypoxic hypoxia. One week later, aerobic muscular performance was determined by swimming test. On the basis of the received data two qualitatively equivalent groups in a ratio 10/48 were formed. After a week of recovery over the next 10 days, one animal remained intact and 5 other rats were exposed to waterimmersion and restraint stress. The next day after stress, the immune testes carried out. Results. Wide variability of hypoxic and swimming tests was revealed. 4 clusters were created retrospectively. Each cluster is characterized by specific (correctness of classification 96%) post-stress changes of 18 Immune parameters (6 from the Thymus, 5 from the Spleen, 7 from the Blood). The swimming test determines the post-stress state of the registered parameters of the Immunity by 46,7%, the hypoxic test - by 25,0%, and taken together - by 50,1%. Conclusion. Innate muscular endurance and resistance to hypoxia significantly determines the Immune parameters after acute stress in rats.